Declining concentrations of dihydroartemisinin in plasma during 5-day oral treatment with artesunate for Falciparum malaria.
نویسندگان
چکیده
Six patients with uncomplicated falciparum malaria received artesunate for 5 days. Plasma concentrations of artesunate and dihydroartemisinin were determined by high-performance liquid chromatography with electrochemical detection. The concentrations of dihydroartemisinin in plasma 2 h after a dose showed a time-dependent decline. Concentrations of artesunate in plasma especially after the last dose, were very low. Despite this, all patients responded with a fast recovery.
منابع مشابه
Opposite malaria and pregnancy effect on oral bioavailability of artesunate – a population pharmacokinetic evaluation
AIM The aim was to compare the pharmacokinetic properties of artesunate and dihydroartemisinin in the same women: i) pregnant with acute uncomplicated malaria on day 1 and 2, ii) pregnant with convalescent malaria on day 7 and iii) in a healthy state 3 months post-partum on day 1, 2 and 7. METHODS Non-linear mixed-effects modelling was used to compare plasma concentration-time profiles of art...
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عنوان ژورنال:
- Antimicrobial agents and chemotherapy
دوره 43 3 شماره
صفحات -
تاریخ انتشار 1999